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Microtubule-associated nuclear envelope proteins in interphase and mitosis
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0003-1476-6675
Stockholm University, Faculty of Science, Department of Neurochemistry. Karolinska Institutet, Sweden.
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0003-2092-457X
2011 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 39, 1786-1789 p.Article in journal (Refereed) Published
Abstract [en]

The LINC (linker of nucleoskeleton and cytoskeleton) complex forms a transcisternal bridge across the NE (nuclear envelope) that connects the cytoskeleton with the nuclear interior. This enables some proteins of the NE to communicate with the centrosome and the microtubule cytoskeleton. The position of the centrosome relative to the NE is of vital importance for many cell functions, such as cell migration and division, and centrosomal dislocation is a frequent phenotype in laminopathic disorders. Also in mitosis, a small group of transmembrane NE proteins associate with microtubules when they concentrate in a specific membrane domain associated with the mitotic spindle. The present review discusses structural and functional aspects of microtubule association with NE proteins and how this association may be maintained over the cell cycle.

Place, publisher, year, edition, pages
2011. Vol. 39, 1786-1789 p.
Keyword [en]
centrosome, integral inner nuclear membrane protein, linker of nucleoskeleton and cytoskeleton complex (LINC complex), mitosis, nuclear envelope, spindle endomembrane
National Category
Biological Sciences Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-71132DOI: 10.1042/BST20110680ISI: 000298200000042OAI: oai:DiVA.org:su-71132DiVA: diva2:483982
Note

authorCount :3

Available from: 2012-01-26 Created: 2012-01-26 Last updated: 2017-12-08Bibliographically approved

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Figueroa, Ricardo A.Gudise, SanthoshHallberg, Einar
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