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The dimensionality of between-person differences in white matter microstructure in old age
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Max Planck Inst Human Dev, Ctr Lifespan Psychol, Berlin, Germany.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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2013 (English)In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 34, no 6, 1386-1398 p.Article in journal (Refereed) Published
Abstract [en]

Between-person differences in white matter microstructure may partly generalize across the brain and partly play out differently for distinct tracts. We used diffusion-tensor imaging and structural equation modeling to investigate this issue in a sample of 260 adults aged 60–87 years. Mean fractional anisotropy and mean diffusivity of seven white matter tracts in each hemisphere were quantified. Results showed good fit of a model positing that individual differences in white matter microstructure are structured according to tracts. A general factor, although accounting for variance in the measures, did not adequately represent the individual differences. This indicates the presence of a substantial amount of tract-specific individual differences in white matter microstructure. In addition, individual differences are to a varying degree shared between tracts, indicating that general factors also affect white matter microstructure. Age-related differences in white matter microstructure were present for all tracts. Correlations among tract factors did not generally increase as a function of age, suggesting that aging is not a process with homogenous effects on white matter microstructure across the brain. These findings highlight the need for future research to examine whether relations between white matter microstructure and diverse outcomes are specific or general. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.

Place, publisher, year, edition, pages
2013. Vol. 34, no 6, 1386-1398 p.
Keyword [en]
white matter microstructure, individual differences, age differences, structural equation modeling
National Category
Neurosciences Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:su:diva-74169DOI: 10.1002/hbm.21518ISI: 000317855400012OAI: oai:DiVA.org:su-74169DiVA: diva2:506924
Funder
FAS, Swedish Council for Working Life and Social Research
Available from: 2012-03-01 Created: 2012-03-01 Last updated: 2017-12-07Bibliographically approved

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Human Brain Mapping
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