The paper examines the approaches to management and settlement of inter-state disputes and their implications for regional collaboration in the Southeast Asian Region. The focus of the paper is on approaches to management and settlement of border and territorial disputes between the ten member states of the Association of Southeast Asian Nations (ASEAN). First the paper provides an overview of achievements in management and settlement as well as of remaining challenges of unsettled disputes. Then the paper outlines the core elements of ASEAN’s framework of dispute settlement mechanisms. In assessing the implications for regional collaboration, the focal point of analysis is on the relationship between bilateral approaches and the regional framework for dispute settlement established through ASEAN. A key dimension is an assessment of whether bilateral approaches strengthen or weaken the ASEAN framework.