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Peanut sensitization during the first five years of life is associated with elevated levels of peanut-specific IgG
Stockholm University, Faculty of Science, The Wenner-Gren Institute .
Stockholm University, Faculty of Science, The Wenner-Gren Institute .
2012 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 23, no 3, 224-229 p.Article in journal (Refereed) Published
Abstract [en]

Background: Allergen-specific IgE antibodies are implicated in allergic diseases while allergen-specific IgG antibodies have been proposed to prevent allergic reactions. The objective for this study was to study if the immune response (IgG and IgG4) to peanut differs in IgE sensitized and non-sensitized young children.

Methods: A total of 239 children have been followed prospectively from birth to 5 years of age. Levels of IgG and IgG4 to peanut, Ara h 2 and Ara h 8 were analyzed at 2 and 5 years of age and related to IgE-sensitization and peanut consumption.

Results:  Levels of peanut-specific IgG and IgG4 were significantly higher in peanut-sensitized children at 2 and 5 years of age when compared to non-sensitized children and children sensitized to other food/inhalant allergens. A strong correlation was seen between levels of peanut-specific IgG/IgG4-ratios and peanut-specific IgE at 5 years of age. Children avoiding peanuts, a subgroup of the peanut sensitized, had statistically significant higher levels of IgE to peanut and a tendency of higher IgG and IgG4 levels to peanut. In the avoidance-group significant correlations between IgE and IgG/IgG4 to peanut was found compared to children eating peanuts. 

Conclusion: Peanut-specific IgG or IgG4 levels were elevated in peanut-sensitized children especially those avoiding peanuts. In our study, IgG and IgG4 do not seem to indicate tolerance or protection from sensitization.

Place, publisher, year, edition, pages
2012. Vol. 23, no 3, 224-229 p.
Keyword [en]
Ara h 2, Ara h 8, IgE, IgG, IgG4, peanut, sensitization
National Category
Respiratory Medicine and Allergy Immunology in the medical area
Research subject
Immunology
Identifiers
URN: urn:nbn:se:su:diva-75737DOI: 10.1111/j.1399-3038.2012.01290.xISI: 000302934400003OAI: oai:DiVA.org:su-75737DiVA: diva2:523780
Funder
Swedish Research Council, K2010-57X-15160-07-03
Available from: 2012-12-20 Created: 2012-04-26 Last updated: 2017-12-07Bibliographically approved

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