Peptide Nanoparticles for Oligonucleotide Delivery
2011 (English)In: Progress in Molecular Biology and Translational Science: Nanoparticles in Translational Science and Medicine / [ed] Villaverde, A., Elsevier Academic Press , 2011, 397-426 p.Chapter in book (Refereed)
In the past two decades, different methods have emerged for intervention with gene expression, which can be generally referred to as gene therapy. Oligonucleotides (ONs) and their analogs form the basis of the molecules that can be used to modulate gene expression. Unfortunately, due to their physicochemical properties, these molecules require assistance in their intracellular delivery. Cell-penetrating peptides (CPPs) are one class of nonviral delivery vectors that, because of their remarkable translocation properties, have been intensely utilized for the delivery, of ON-based molecules, both in vitro and in vivo. This chapter concentrates on the applications of CPPs that directly form nanopartides with different ONs and facilitate their intracellular delivery.
Place, publisher, year, edition, pages
Elsevier Academic Press , 2011. 397-426 p.
, Progress in Molecular Biology and Translational Science, ISSN 1877-1173 ; 104
IdentifiersURN: urn:nbn:se:su:diva-75322DOI: 10.1016/B978-0-12-416020-0.00010-3ISI: 000299296000010ISBN: 978-0-12-416020-0OAI: oai:DiVA.org:su-75322DiVA: diva2:524394