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Design of an Integrated Process of Chromatography, Crystallization and Racemization for the Resolution of 2 ',6 '-Pipecoloxylidide (PPX)
Stockholm University, Faculty of Science, Department of Organic Chemistry.
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2012 (English)In: Organic Process Research & Development, ISSN 1083-6160, E-ISSN 1520-586X, Vol. 16, no 2, 343-352 p.Article in journal (Refereed) Published
Abstract [en]

An integrated process for the chiral separation of the industrially relevant substance 2',6'-pipecoloxylidide (PPX), an intermediate in the manufacture of a number of anesthetics, was developed. By combining three different techniques, chromatography, crystallization, and racemization, high productivity was achieved. All unit operations were executed using a common solvent system, full recycling, and a minimum of solvent exchanges or removals. The target molecule was obtained with an enantiopurity of >99.5 wt %.

Place, publisher, year, edition, pages
2012. Vol. 16, no 2, 343-352 p.
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Organic Chemistry
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URN: urn:nbn:se:su:diva-76346DOI: 10.1021/op200268hISI: 000300339700023OAI: oai:DiVA.org:su-76346DiVA: diva2:526392
Note
13Available from: 2012-05-11 Created: 2012-05-10 Last updated: 2017-12-07Bibliographically approved

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