Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms
2012 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 510, no 2, 121-126 p.Article in journal (Refereed) Published
Investigate possible associations of white matter hyperintensities (WMHs) with the metabolism of cholesterol and insulin in two subgroups of patients with memory complaints and different CSF A beta 42 and CSF tau levels. 59 patients from the memory clinic at Karolinska Hospital were included. Degree of WMHs was rated using the ARWMC scale and the following biomarkers were measured in CSF and plasma: insulin, cholesterol, lanosterol, lathosterol, and oxidized cholesterol metabolites. The WMHs in CSF control-like group correlated with increased brain cholesterol synthesis and reduced efflux of oxysterols and insulin in CSF. In the CSF AD-like group, the WMHs correlated with increased peripheral cholesterol metabolism. Despite having similar appearance on FLAIR images, the pathogenic mechanisms of WMHS are likely to be different in the two groups investigated.
Place, publisher, year, edition, pages
2012. Vol. 510, no 2, 121-126 p.
Alzheimer disease, Cholesterol, Oxysterols, Hyperintensities, A beta 42, Tau
IdentifiersURN: urn:nbn:se:su:diva-77002DOI: 10.1016/j.neulet.2012.01.017ISI: 000301401300011OAI: oai:DiVA.org:su-77002DiVA: diva2:528773