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Effect studies of human pharmaceuticals on Fucus vesiculosus and Gammarus spp
Stockholm University, Faculty of Science, Department of Systems Ecology.
Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
Stockholm University, Faculty of Science, Department of Systems Ecology.
Stockholm University, Faculty of Science, Department of Systems Ecology.
2012 (English)In: Marine Environmental Research, ISSN 0141-1136, E-ISSN 1879-0291, Vol. 74, 1-8 p.Article in journal (Refereed) Published
Abstract [en]

In two experiments, the human pharmaceutical propranolol negatively affected the physiology of two test organisms, Fucus vesiculosus and Gammarus spp. from a Baltic Sea littoral community in a concentration of 1000 mu g l(-1). Some effects were also observed for the lower, more ecologically relevant concentrations (10 mu g l(-1) and 100 mu g l(-1)). The effects on E vesiculosus not only increased with increasing concentration, but also with exposure time; while the effects on Gammarus spp. were more inconsistent over time. No clear effects of the pharmaceuticals diclofenac and ibuprofen were observed for any of the organisms. Physiological parameters measured were GP:R-ratio, chlorophyll fluorescence and release of coloured dissolved organic matter, respiration and ammonium excretion. Pharmaceutical substances are repeatedly detected in the Baltic Sea which is the recipient for SIP effluents from more than 85 million people living in the catchment area, but the knowledge of their effects on non-target organisms is still very limited.

Place, publisher, year, edition, pages
2012. Vol. 74, 1-8 p.
Keyword [en]
Baltic Sea, Sub-lethal effects, Algae, Amphipod, beta-blocker, NSAID
National Category
Biological Sciences Earth and Related Environmental Sciences
URN: urn:nbn:se:su:diva-76976DOI: 10.1016/j.marenvres.2011.11.001ISI: 000300819000001OAI: diva2:533636


Available from: 2012-06-14 Created: 2012-05-28 Last updated: 2014-03-03Bibliographically approved
In thesis
1. Pharmaecological perspectives: Exposure studies using coastal Baltic Sea organisms
Open this publication in new window or tab >>Pharmaecological perspectives: Exposure studies using coastal Baltic Sea organisms
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis investigates the effects of pharmaceutical substances on coastal Baltic Sea organisms. Despite an increasing awareness of the occurrence of pharmaceuticals in various aquatic compartments, current knowledge of their possible effects on non-target organisms is limited. Especially scarce is the knowledge concerning possible long-term effects, mixture-effects, effects on non-standard test organisms and indirect effects from interactions among organisms. Also the environmental fate, availability and distribution of pharmaceuticals between sediment, water and biota is only rarely investigated.

The aim of this thesis was therefore to investigate the biological effects of pharmaceuticals, and their distribution in organisms of a coastal Baltic Sea community. In four studies, blue mussels, amphipods and macroalgae were exposed to pharmaceuticals in laboratory experiments. The effects from exposure, as well as recovery from the same, were studied on different physiological variables. With increasing complexity of experiment designs, the tested substances were found to affect aquatic organisms from different hierarchical levels both through direct negative effects, as well as through indirect positive effects within model communities. Moreover, the studies showed that the organisms were affected by exposure to environmentally relevant concentrations, but also that exposed organisms could recover from the exposure. Effects from pharmaceutical mixtures occurred in lower concentrations than effects from single pharmaceutical substances, and high internal concentrations of two pharmaceuticals – diclofenac and propranolol – were detected in exposed organisms.

The detected effects and the uptake of pharmaceuticals in biota demonstrate a possible problem for aquatic environments, but especially for the Baltic Sea, since this is a naturally sensitive ecosystem with low species diversity, low functional redundancy and a history of heavy pollution.

Place, publisher, year, edition, pages
Stockholm: Department of Ecology, Environment and Plant Sciences, Stockholm Univeristy, 2014. 58 p.
Pharmaceuticals, Baltic Sea, Mytilus edulis trossulus, Fucus vesiculosus, Ceramium tenuicorne, Gammarus spp., Direct effects, Inter-specific interactions
National Category
Research subject
Marine Ecotoxicology
urn:nbn:se:su:diva-101160 (URN)978-91-7447-871-6 (ISBN)
Public defence
2014-04-04, Nordenskiöldsalen, Geovetenskapens hus, Svante Arrhenius väg 12, Stockholm, 13:30 (English)

At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Manuscript. Paper 4: Manuscript.

Available from: 2014-03-13 Created: 2014-02-27 Last updated: 2016-05-06Bibliographically approved

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Oskarsson, HannaEriksson Wiklund, Ann-KristinKumblad, Linda
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