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Prostate alpha/beta revisited - an analysis of clinical results from 14168 patients
Linköping University, Sweden.ORCID iD: 0000-0001-8171-2541
Stockholm University, Faculty of Science, Department of Physics. Karolinska Institutet, Sweden.ORCID iD: 0000-0002-7101-240X
2012 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 51, no 8, 963-974 p.Article, review/survey (Refereed) Published
Abstract [en]

Purpose: To determine the dose response parameters and the fractionation sensitivity of prostate tumours from clinical results of patients treated with external beam radiotherapy.

Material and methods: The study was based on 5-year biochemical results from 14168 patients treated with external beam radiotherapy. Treatment data from 11330 patients treated with conventional fractionation have been corrected for overall treatment time and fitted with a logit equation. The results have been used to determine the optimum α/β values that minimise differences in predictions from 2838 patients treated with hypofractionated schedules.

Results: Conventional fractionation data yielded logit dose response parameters for all risk groups and for all definitions of biochemical failures. The analysis of hypofractionation data led to very low α/β values (1-1.7 Gy) in all mentioned cases. Neglecting the correction for overall treatment time has little impact on the derivation of α/β values for prostate cancers.

Conclusions: These results indicate that the high fractionation sensitivity is an intrinsic property of prostate carcinomas and they support the use of hypofractionation to increase the therapeutic gain for these tumours.

Place, publisher, year, edition, pages
2012. Vol. 51, no 8, 963-974 p.
Keyword [en]
Prostate cancer, radiotherapy, alpha/beta, LQ model
National Category
Cancer and Oncology
Research subject
Radiation Physics; Oncology
URN: urn:nbn:se:su:diva-79116DOI: 10.3109/0284186X.2012.719635ISI: 000309747100001OAI: diva2:547452
Available from: 2012-08-28 Created: 2012-08-28 Last updated: 2015-06-15Bibliographically approved

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Dasu, AlexandruToma-Dasu, Iuliana
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