Electrophilic Trifluoromethylation by Copper-Catalyzed Addition of CF3-Transfer Reagents to Alkenes and Alkynes
2012 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 14, no 11, 2882-2885 p.Article in journal (Refereed) Published
Regio- and stereoselective Cu-catalyzed addition of the above hypervalent iodine reagent to alkynes and alkenes was achieved. In the presence of Cul, the reaction is suitable to perform trifluoromethyl-benzoyloxylation and trifluoromethyl-halogenation of alkenes and alkynes. Electron-donating substituents accelerate the process, and alkenes react faster than alkynes emphasizing the electrophilic character of the addition reaction.
Place, publisher, year, edition, pages
2012. Vol. 14, no 11, 2882-2885 p.
IdentifiersURN: urn:nbn:se:su:diva-79887DOI: 10.1021/ol3011419ISI: 000304682700058OAI: oai:DiVA.org:su-79887DiVA: diva2:551839
FunderSwedish Research CouncilKnut and Alice Wallenberg Foundation