Change search
ReferencesLink to record
Permanent link

Direct link
Cell-penetrating peptides for the delivery of nucleic acids
Stockholm University, Faculty of Science, Department of Neurochemistry. University of Tartu, Estonia.ORCID iD: 0000-0001-6107-0844
2012 (English)In: Expert Opinion on Drug Delivery, ISSN 1742-5247, Vol. 9, no 7, 823-836 p.Article, review/survey (Refereed) Published
Abstract [en]

Introduction: Different gene therapy approaches have gained extensive interest lately and, after many initial hurdles, several promising approaches have reached to the clinics. Successful implementation of gene therapy is heavily relying on finding efficient measures to deliver genetic material to cells. Recently, non-viral delivery of nucleic acids and their analogs has gained significant interest. Among non-viral vectors, cell-penetrating peptides (CPPs) have been extensively used for the delivery of nucleic acids both in vitro and in vivo. Areas covered: In this review we will discuss recent advances of CPP-mediated delivery of nucleic acid-based cargo, concentrating on the delivery of plasmid DNA, splice-correcting ONs, and small-interfering RNAs. Expert opinion: CPPs have proved their potential as carriers for nucleic acids. However, similarly to other non-viral vectors, CPPs require further development, as efficient systemic delivery is still seldom achieved. To achieve this, CPPs should be modified with entities that would allow better endosomal escape, targeting of specific tissues and cells, and shielding agents that increase the half-life of the vehicles. Finally, to understand the clinical potential of CPPs, they require more thorough investigations in clinically relevant disease models and in pre-clinical and clinical studies.

Place, publisher, year, edition, pages
2012. Vol. 9, no 7, 823-836 p.
Keyword [en]
cell-penetrating peptide, gene delivery, nanoparticle, oligonucleotide delivery, siRNA delivery
National Category
Pharmacology and Toxicology
URN: urn:nbn:se:su:diva-80041DOI: 10.1517/17425247.2012.689285ISI: 000305478200008OAI: diva2:551946


Available from: 2012-09-12 Created: 2012-09-12 Last updated: 2015-04-21Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Langel, Ülo
By organisation
Department of Neurochemistry
In the same journal
Expert Opinion on Drug Delivery
Pharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 10 hits
ReferencesLink to record
Permanent link

Direct link