Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys
2012 (English)In: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 33, no 4, 441-451 p.Article in journal (Refereed) Published
Perfluorohexanesulfonate (PFHxS) has been found in biological samples from wildlife and humans. The human geometric mean serum PFHxS elimination half-life has been estimated to be 2665 days. A series of studies was undertaken to establish pharmacokinetic parameters for PFHxS in rats, mice, and monkeys after single administration with pharmacokinetic parameters determined by WinNonlin (R) software. Rats and mice appeared to be more effective at eliminating PFHxS than monkeys. With the exception of female rats, which had serum PFHxS elimination half-life of approximately 2 days, the serum elimination half-lives in the rodent species and monkeys approximated 1 month and 4 months, respectively, when followed over extended time periods (10-24 weeks). Collectively, these studies provide valuable insight for human health risk assessment regarding the potential for accumulation of PFHxS in humans.
Place, publisher, year, edition, pages
2012. Vol. 33, no 4, 441-451 p.
Perfluorohexanesulfonate, PFHxS, Pharmacokinetics, Rats, Monkeys, Mice
IdentifiersURN: urn:nbn:se:su:diva-80032DOI: 10.1016/j.reprotox.2011.07.004ISI: 000305303100005OAI: oai:DiVA.org:su-80032DiVA: diva2:552006