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Recent developments in applications of cell penetrating peptides uptake mechanisms and oligonucleotide delivery
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-9912-4887
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-6107-0844
2012 (English)In: Chimica oggi, ISSN 0392-839X, E-ISSN 1973-8250, Vol. 30, no 2, 10-12 p.Article in journal (Refereed) Published
Abstract [en]

Here we report on recent developments in cell-penetrating peptide mediated delivery of siRNA and other oligonucleotides. We also report on the latest discoveries regarding the debated uptake mechanism of cell-penetrating peptides. For the first time evidence of a cell surface receptor involvement in the uptake of cell-penetrating peptide/oligonucleotide complexes has been described, indicating that properties of the cargo are likely crucial for which pathway is responsible for uptake.

Place, publisher, year, edition, pages
2012. Vol. 30, no 2, 10-12 p.
Keyword [en]
Cell-penetrating peptides, siRNA, Oligonucleotide delivery, Scavenger receptors
National Category
Neurology Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-80154ISI: 000305141900003OAI: oai:DiVA.org:su-80154DiVA: diva2:552322
Note

AuthorCount:2;

Available from: 2012-09-13 Created: 2012-09-12 Last updated: 2017-12-07Bibliographically approved

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