Recent developments in applications of cell penetrating peptides uptake mechanisms and oligonucleotide delivery
2012 (English)In: Chimica oggi, ISSN 0392-839X, Vol. 30, no 2, 10-12 p.Article in journal (Refereed) Published
Here we report on recent developments in cell-penetrating peptide mediated delivery of siRNA and other oligonucleotides. We also report on the latest discoveries regarding the debated uptake mechanism of cell-penetrating peptides. For the first time evidence of a cell surface receptor involvement in the uptake of cell-penetrating peptide/oligonucleotide complexes has been described, indicating that properties of the cargo are likely crucial for which pathway is responsible for uptake.
Place, publisher, year, edition, pages
2012. Vol. 30, no 2, 10-12 p.
Cell-penetrating peptides, siRNA, Oligonucleotide delivery, Scavenger receptors
Neurology Chemical Sciences
IdentifiersURN: urn:nbn:se:su:diva-80154ISI: 000305141900003OAI: oai:DiVA.org:su-80154DiVA: diva2:552322