Change search
ReferencesLink to record
Permanent link

Direct link
Heterologous prime-boost regimen adenovector 35-circumsporozoite protein vaccine/recombinant Bacillus Calmette-Guerin expressing the Plasmodium falciparum circumsporozoite induces enhanced long-term memory immunity in BALB/c mice
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
Show others and affiliations
2012 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 30, no 27, 4040-4045 p.Article in journal (Refereed) Published
Abstract [en]

Background: Sustained antibody levels are a hallmark of immunity against many pathogens, and induction of long-term durable antibody titers is an essential feature of effective vaccines. Heterologous prime-boost approaches with vectors are optimal strategies to improve a broad and prolonged immunogenicity of malaria vaccines. Results: In this study, we demonstrate that the heterologous prime-boost regimen Ad35-CS/BCG-CS induces stronger immune responses by enhancing type 1 cellular producing-cells with high levels of CSp-specific IFN-gamma and cytophilic IgG2a antibodies as compared to a homologous BCG-CS and a heterologous BCG-CS/CSp prime-boost regimen. Moreover, the heterologous prime-boost regimen elicits the highest level of LLPC-mediated immune responses. Conclusion: The increased IFN-gamma-producing cell responses induced by the combination of Ad35-CS/BCG-CS and sustained type 1 antibody profile together with high levels of LLPCs may be essential for the development of long-term protective immunity against liver-stage parasites.

Place, publisher, year, edition, pages
2012. Vol. 30, no 27, 4040-4045 p.
Keyword [en]
Malaria vaccines, Plasmodium falciparum circumsporozoite protein, Heterologous prime-boost, Ad35-CS, BCC-CS, Long-lived plasma cells
National Category
URN: urn:nbn:se:su:diva-79999DOI: 10.1016/j.vaccine.2012.04.029ISI: 000305660800011OAI: diva2:555304


Available from: 2012-09-19 Created: 2012-09-12 Last updated: 2012-10-25Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Arama, CharlesFernández, CarmenTroye-Blomberg, Marita
By organisation
In the same journal

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 139 hits
ReferencesLink to record
Permanent link

Direct link