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Heterologous prime-boost regimen adenovector 35-circumsporozoite protein vaccine/recombinant Bacillus Calmette-Guerin expressing the Plasmodium falciparum circumsporozoite induces enhanced long-term memory immunity in BALB/c mice
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
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2012 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 30, no 27, 4040-4045 p.Article in journal (Refereed) Published
Abstract [en]

Background: Sustained antibody levels are a hallmark of immunity against many pathogens, and induction of long-term durable antibody titers is an essential feature of effective vaccines. Heterologous prime-boost approaches with vectors are optimal strategies to improve a broad and prolonged immunogenicity of malaria vaccines. Results: In this study, we demonstrate that the heterologous prime-boost regimen Ad35-CS/BCG-CS induces stronger immune responses by enhancing type 1 cellular producing-cells with high levels of CSp-specific IFN-gamma and cytophilic IgG2a antibodies as compared to a homologous BCG-CS and a heterologous BCG-CS/CSp prime-boost regimen. Moreover, the heterologous prime-boost regimen elicits the highest level of LLPC-mediated immune responses. Conclusion: The increased IFN-gamma-producing cell responses induced by the combination of Ad35-CS/BCG-CS and sustained type 1 antibody profile together with high levels of LLPCs may be essential for the development of long-term protective immunity against liver-stage parasites.

Place, publisher, year, edition, pages
2012. Vol. 30, no 27, 4040-4045 p.
Keyword [en]
Malaria vaccines, Plasmodium falciparum circumsporozoite protein, Heterologous prime-boost, Ad35-CS, BCC-CS, Long-lived plasma cells
National Category
Immunology
Identifiers
URN: urn:nbn:se:su:diva-79999DOI: 10.1016/j.vaccine.2012.04.029ISI: 000305660800011OAI: oai:DiVA.org:su-79999DiVA: diva2:555304
Note

AuthorCount:8;

Available from: 2012-09-19 Created: 2012-09-12 Last updated: 2017-12-07Bibliographically approved

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