Psychotropics and alcohol are psychoactive substances with different cultural meanings and opposing gender associations. This paper examines the Swedish press debate ongender and psychotropics and compares it with the press debate on gender and alcohol, aiming toidentify the conditions under which gendered moral boundaries of acceptable/unacceptableconsumption are defended. The study shows that boundaries acquire a heightened moral status innews stories (1) that deal with a topic related to cultural ideas about essential gender difference,(2) where the cultural status of the psychoactive substance is linked to selfish and/or hedonisticmotives, and (3) where innocent victims of consumption can be identified. Moreover, it shows thatthe “bad” characters constructed through this moral boundary are portrayed as exhibiting“excessive masculinity” and “insufficient femininity”. On the basis of these findings, it is arguedthat newspaper discourse on psychotropics and alcohol still relies quite heavily on gendered andheteronormative ideas.