Change search
ReferencesLink to record
Permanent link

Direct link
YAP1 Recruits c-Abl to Protect Angiomotin-Like 1 from Nedd4-Mediated Degradation
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Developmental Biology.
2012 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 7, no 4, e35735- p.Article in journal (Refereed) Published
Abstract [en]

Background: Tissue development and organ growth require constant remodeling of cell-cell contacts formed between epithelial cells. The Hippo signaling cascade curtails organ growth by excluding the transcriptional co-activator Yes Associated Protein 1 (YAP1) from the nucleus. Angiomotin family members recruit YAP1 to tight junctions [1], but whether YAP1 plays a specific role outside of the nucleus is currently unknown. Methodology/Principal Findings: The present study demonstrates that the E3 ubiquitin ligase Nedd4.2 targets Angiomotin-like 1 (AMOTL1), a family member that promotes the formation of epithelial tight junctions, for ubiquitin-dependent degradation. Unexpectedly, YAP1 antagonizes the function of Nedd4.2, and protects AMOTL1 against Nedd4.2-mediated degradation. YAP1 recruits c-Abl, a tyrosine kinase that binds and phosphorylates Nedd4.2 on tyrosine residues, thereby modifying its ubiquitin-ligase activity. Conclusions/Significance: Our results uncover a novel function for cytoplasmic YAP1. YAP1 recruits c-Abl to protect AMOTL1 against Nedd4.2-mediated degradation. Thus, YAP1, excluded from the nucleus, contributes to the maintenance of tight junctions.

Place, publisher, year, edition, pages
2012. Vol. 7, no 4, e35735- p.
National Category
Other Medical Biotechnology
URN: urn:nbn:se:su:diva-80758DOI: 10.1371/journal.pone.0035735ISI: 000305336000054OAI: diva2:557803


Available from: 2012-09-29 Created: 2012-09-27 Last updated: 2012-09-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Skouloudaki, Kassiani
By organisation
Developmental Biology
In the same journal
Other Medical Biotechnology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 21 hits
ReferencesLink to record
Permanent link

Direct link