LytA, Major Autolysin of Streptococcus pneumoniae, Requires Access to Nascent Peptidoglycan
2012 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 287, no 14, 11018-11029 p.Article in journal (Refereed) Published
Background: The regulation of cell wall hydrolysis by the pneumococcal autolysin LytA is poorly understood. Results: The cell wall is susceptible to extracellular LytA only during the stationary phase or after cell wall synthesis inhibition. Conclusion: LytA is regulated on the substrate level, where peptidoglycan modifications likely prevent LytA hydrolysis. Significance: The control of amidases is essential for bacterial survival, cell-wall synthesis, and division.
Place, publisher, year, edition, pages
2012. Vol. 287, no 14, 11018-11029 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:su:diva-80727DOI: 10.1074/jbc.M111.318584ISI: 000302780100030OAI: oai:DiVA.org:su-80727DiVA: diva2:558716