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LytA, Major Autolysin of Streptococcus pneumoniae, Requires Access to Nascent Peptidoglycan
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
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2012 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 287, no 14, 11018-11029 p.Article in journal (Refereed) Published
Abstract [en]

Background: The regulation of cell wall hydrolysis by the pneumococcal autolysin LytA is poorly understood. Results: The cell wall is susceptible to extracellular LytA only during the stationary phase or after cell wall synthesis inhibition. Conclusion: LytA is regulated on the substrate level, where peptidoglycan modifications likely prevent LytA hydrolysis. Significance: The control of amidases is essential for bacterial survival, cell-wall synthesis, and division.

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2012. Vol. 287, no 14, 11018-11029 p.
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:su:diva-80727DOI: 10.1074/jbc.M111.318584ISI: 000302780100030OAI: oai:DiVA.org:su-80727DiVA: diva2:558716
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AuthorCount:8;

Available from: 2012-10-04 Created: 2012-09-27 Last updated: 2017-12-07Bibliographically approved

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