Kinetic resolution of diarylmethanols using a mutated variant of lipase CALB
2012 (English)In: Tetrahedron, ISSN 0040-4020, E-ISSN 1464-5416, Vol. 68, no 37, 7613-7618 p.Article in journal (Refereed) Published
An enzymatic kinetic resolution of diarylmethanols via acylation has been developed. This was achieved by the use of a mutated variant of CALB that accepts larger substrates compared to the wild type. By the use of diarylmethanols with two differently sized aryl groups, enantioselective transformations were achieved. A larger size-difference led to a higher enantioselectivity. In addition, substrates with electronically different aryl groups, such as phenyl and pyridyl, also gave an enantioselective reaction. The highest E value was observed with a substrate where steric and electronic effects were combined.
Place, publisher, year, edition, pages
2012. Vol. 68, no 37, 7613-7618 p.
Kinetic resolution, Diarylmethanols, Biotransformation, Candida antarctica lipase B, Enzymatic resolution
IdentifiersURN: urn:nbn:se:su:diva-81263DOI: 10.1016/j.tet.2012.06.040ISI: 000307802300013OAI: oai:DiVA.org:su-81263DiVA: diva2:560575
FunderSwedish Research CouncilKnut and Alice Wallenberg Foundation