Trifluoromethylation of Propargylic Halides and Trifluoroacetates Using (Ph3P)(3)Cu(CF3) Reagent
2012 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 14, no 15, 3966-3969 p.Article in journal (Refereed) Published
A copper-mediated trifluoromethylation of propargylic halides and trifluoroacetates was performed with high allenyl or propargyl selectivity. The reaction proceeds smoothly with aliphatic and aromatic substituents bearing either electron-withdrawing or -supplying groups. Preliminary mechanistic results indicate an ionic mechanism involving nucleophilic transfer of the CF3 group from the Cu complex to the propargylic substrate.
Place, publisher, year, edition, pages
2012. Vol. 14, no 15, 3966-3969 p.
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-81577DOI: 10.1021/ol3017287ISI: 000307041600040OAI: oai:DiVA.org:su-81577DiVA: diva2:563155
FunderSwedish Research CouncilKnut and Alice Wallenberg Foundation