Determination of perfluoroalkyl carboxylic, sulfonic, and phosphonic acids in food
2012 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 404, no 8, 2193-2201 p.Article in journal (Refereed) Published
A sensitive and accurate method was developed and validated for simultaneous analysis of perfluoroalkyl carboxylic acids, sulfonic acids, and phosphonic acids (PFPAs) at low picograms per gram concentrations in a variety of food matrices. The method employed extraction with acetonitrile/water and cleanup on a mixed-mode co-polymeric sorbent (C8 + quaternary amine) using solid-phase extraction. High-performance liquid chromatographic separation was achieved on a C18 column using a mobile phase gradient containing 5 mM 1-methyl piperidine for optimal chromatographic resolution of PFPAs. A quadrupole time-of-flight high-resolution mass spectrometer operating in negative ion mode was used as detector. Method detection limits were in the range of 0.002 to 0.02 ng g(-1) for all analytes. Sample preparation (extraction and cleanup) recoveries at a spiking level of 0.1 ng g(-1) to a baby food composite were in the range of 59 to 98 %. A strong matrix effect was observed in the analysis of PFPAs in food extracts, which was tentatively assigned to sorption of PFPAs to the injection vial in the solvent-based calibration standard. The method was successfully applied to a range of different food matrices including duplicate diet samples, vegetables, meat, and fish samples.
Place, publisher, year, edition, pages
2012. Vol. 404, no 8, 2193-2201 p.
PFCAs, PFSAs, PFPAs, Food samples, HPLC, HRMS
Biochemistry and Molecular Biology
Research subject Applied Environmental Science
IdentifiersURN: urn:nbn:se:su:diva-83037DOI: 10.1007/s00216-012-6374-zISI: 000310083900012OAI: oai:DiVA.org:su-83037DiVA: diva2:574285