Quantification of ultraviolet radiation induced DNA damage in the urine of Swedish adults and children following exposure to sunlight
2012 (English)In: Biomarkers, ISSN 1354-750X, Vol. 17, no 7, 634-641 p.Article in journal (Refereed) Published
Context: DNA damage following exposure to ultraviolet radiation (UVR) is important in skin cancer development. The predominant photoproduct, cyclobutane thymine dimer (T=T), is repaired and excreted in the urine, where it provides a biomarker of exposure. Objective: To quantify urinary T=T levels after recreational sunlight exposure in adults and children. Methods: Average UVR doses were measured with personal dosimeters. Urinary T=T was analysed with P-32-postlabelling. Results: Background levels of T=T increased significantly following exposure to sunlight. Amounts of T=T in urine of children and adults were not significantly different after adjusting for area of skin exposed and physiological differences. UVR dose and amounts of T=T correlated for both adults and children. Conclusion: Recreational exposure to sunlight in Sweden induces levels of DNA damage, clearly detectable in urine.
Place, publisher, year, edition, pages
2012. Vol. 17, no 7, 634-641 p.
DNA damage, thymine dimer, sunlight, ultraviolet radiation, urine, P-32-postlabelling
IdentifiersURN: urn:nbn:se:su:diva-83023DOI: 10.3109/1354750X.2012.709881ISI: 000310077200008OAI: oai:DiVA.org:su-83023DiVA: diva2:574423