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Quantification of ultraviolet radiation induced DNA damage in the urine of Swedish adults and children following exposure to sunlight
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
2012 (English)In: Biomarkers, ISSN 1354-750X, Vol. 17, no 7, 634-641 p.Article in journal (Refereed) Published
Abstract [en]

Context: DNA damage following exposure to ultraviolet radiation (UVR) is important in skin cancer development. The predominant photoproduct, cyclobutane thymine dimer (T=T), is repaired and excreted in the urine, where it provides a biomarker of exposure. Objective: To quantify urinary T=T levels after recreational sunlight exposure in adults and children. Methods: Average UVR doses were measured with personal dosimeters. Urinary T=T was analysed with P-32-postlabelling. Results: Background levels of T=T increased significantly following exposure to sunlight. Amounts of T=T in urine of children and adults were not significantly different after adjusting for area of skin exposed and physiological differences. UVR dose and amounts of T=T correlated for both adults and children. Conclusion: Recreational exposure to sunlight in Sweden induces levels of DNA damage, clearly detectable in urine.

Place, publisher, year, edition, pages
2012. Vol. 17, no 7, 634-641 p.
Keyword [en]
DNA damage, thymine dimer, sunlight, ultraviolet radiation, urine, P-32-postlabelling
National Category
URN: urn:nbn:se:su:diva-83023DOI: 10.3109/1354750X.2012.709881ISI: 000310077200008OAI: diva2:574423


Available from: 2012-12-05 Created: 2012-12-03 Last updated: 2012-12-05Bibliographically approved

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Kotova, Natalia
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