Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content
2012 (English)In: Molecular membrane biology, ISSN 0968-7688, E-ISSN 1464-5203, Vol. 29, no 7, 299-308 p.Article in journal (Refereed) Published
The organ content of the mevalonate pathway lipids was investigated in liver-X-receptor (LXR) alpha, beta and double knockout mice. An extensive or moderate increase of total cholesterol in the double KO mice was found in all organs elicited by the increase of the esterified form. In LXR alpha and double KO mice, coenzyme Q (CoQ) was decreased in liver and increased in spleen, thymus and lung, while dolichol was increased in all organs investigated. This effect was confirmed using LXR-agonist GW 3965. Analysis of CoQ distribution in organelles showed that the modifications are present in all cellular compartments and that the increase of the lipid in mitochondria was the result of a net increase of CoQ without changing the number of mitochondria. It appears that LXR influences not only cellular cholesterol homeostasis but also the metabolism of CoQ and dolichol, in an indirect manner.
Place, publisher, year, edition, pages
2012. Vol. 29, no 7, 299-308 p.
Liver-X-receptor, coenzyme Q, cholesterol, dolichol, membrane modification
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:su:diva-83014DOI: 10.3109/09687688.2012.694484ISI: 000310315200009OAI: oai:DiVA.org:su-83014DiVA: diva2:574437
52nd International Conference on the Bioscience of Lipids - Expanding the Horizons of Lipidomics, AUG 30-SEP 03, 2011, Warsaw, POLAND