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Modelling tumour oxygenation, reoxygenation and implications on treatment outcome
Stockholm University, Faculty of Science, Department of Physics. Karolinska Insitutet, Sweden.ORCID iD: 0000-0002-7101-240X
Linköping University, Sweden.ORCID iD: 0000-0001-8171-2541
2013 (English)In: Computational & Mathematical Methods in Medicine, ISSN 1748-670X, E-ISSN 1748-6718, 141087Article, review/survey (Refereed) Published
Abstract [en]

Oxygenation is an important component of the tumour microenvironment ,having a significant impact on the progression and management of cancer. Theoreticaldetermination of tissue oxygenation through simulations of the oxygen transportprocess is a powerful tool to characterise the spatial distribution of oxygenon the microscopic scale and its dynamics and to study its impact on theresponse to radiation. Accurate modelling of tumour oxygenation must take intoaccount important aspects that are specific to tumours, making the quantitativecharacterisation of oxygenation rather difficult. This review aims to discussthe important aspects of modelling tumour oxygenation, reoxygenation andimplications for treatment.

Place, publisher, year, edition, pages
2013. 141087
Keyword [en]
tumour oxygenation, reoxygenation, treatment modelling
National Category
Cancer and Oncology
Research subject
Oncology; Radiation Physics; Medical Radiation Physics
Identifiers
URN: urn:nbn:se:su:diva-84596DOI: 10.1155/2013/141087ISI: 000314153500001OAI: oai:DiVA.org:su-84596DiVA: diva2:580781
Available from: 2012-12-27 Created: 2012-12-27 Last updated: 2017-12-06Bibliographically approved

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