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Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0002-4604-6413
Stockholm University, Faculty of Science, Department of Neurochemistry. Mahidol University, Thailand.ORCID iD: 0000-0003-2265-557X
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-6107-0844
2012 (English)In: Pharmaceuticals, ISSN 1424-8247, E-ISSN 1424-8247, Vol. 5, no 9, 991-1007 p.Article in journal (Refereed) Published
Abstract [en]

Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This review is focused on the cancer applications of cell penetrating peptides as delivery systems; different aspects of drug loading, cargoes and delivery are discussed together with methods for targeted delivery, activatable cell-penetrating peptides and transducible agents coupled to cell-penetrating peptides.

Place, publisher, year, edition, pages
2012. Vol. 5, no 9, 991-1007 p.
Keyword [en]
cell penetrating peptides, cancer, drug delivery, oligonucleotides, siRNA therapeutics, cell targeting peptides
National Category
Biological Sciences Chemical Sciences
Research subject
Neurochemistry with Molecular Neurobiology
Identifiers
URN: urn:nbn:se:su:diva-84936DOI: 10.3390/ph5090991OAI: oai:DiVA.org:su-84936DiVA: diva2:582025
Available from: 2013-01-07 Created: 2013-01-03 Last updated: 2017-12-06Bibliographically approved

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Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies(251 kB)89 downloads
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Type fulltextMimetype application/pdf

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Publisher's full texthttp://www.mdpi.com/1424-8247/5/9/991

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