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Galanin receptors and ligands
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-9671-0354
Stockholm University, Faculty of Science, Department of Neurochemistry.
Stockholm University, Faculty of Science, Department of Neurochemistry. University of Tartu, Estonia.ORCID iD: 0000-0001-6107-0844
2012 (English)In: Frontiers in Endocrinology, ISSN 1664-2392, E-ISSN 1664-2392, Vol. 3, no 146, 1-14 p.Article in journal (Refereed) Published
Abstract [en]

The neuropeptide galanin was first discovered 30 years ago. Today, the galanin family consists of galanin, galanin-like peptide (GALP), galanin-message associated peptide (GMAP), and alarin and this family has been shown to be involved in a wide variety of biological and pathological functions. The effect is mediated through three GPCR subtypes, GalR1-3. The limited number of specific ligands to the galanin receptor subtypes has hindered the understanding of the individual effects of each receptor subtype. This review aims to summarize the current data of the importance of the galanin receptor subtypes and receptor subtype specific agonists and antagonists and their involvement in different biological and pathological functions.

Place, publisher, year, edition, pages
2012. Vol. 3, no 146, 1-14 p.
Keyword [en]
galanin, galanin-like peptide, GMAP, alarin, epilepsy
National Category
Biological Sciences Chemical Sciences
Research subject
Neurochemistry with Molecular Neurobiology
Identifiers
URN: urn:nbn:se:su:diva-84939DOI: 10.3389/fendo.2012.00146PubMedID: 23233848OAI: oai:DiVA.org:su-84939DiVA: diva2:582043
Available from: 2013-01-07 Created: 2013-01-03 Last updated: 2017-12-06Bibliographically approved

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Webling, Kristin E. B.Runesson, JohanLangel, Ülo
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