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Novel Galanin Receptor Subtype Specific Ligand in Depression Like Behavior
Stockholm University, Faculty of Science, Department of Neurochemistry. University of Tartu, Estonia.
Stockholm University, Faculty of Science, Department of Neurochemistry.
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2013 (English)In: Neurochemical Research, ISSN 0364-3190, E-ISSN 1573-6903, Vol. 38, no 2, 398-404 p.Article in journal (Refereed) Published
Abstract [en]

Neuropeptide galanin and its three receptors, galanin receptor type 1-galanin receptor type 3, are known to be involved in the regulation of numerous psychological processes, including depression. Studies have suggested that stimulation of galanin receptor type 2 (GalR2) leads to attenuation of the depression-like behavior in animals. However, due to the lack of highly selective galanin subtype specific ligands the involvement of different receptors in depression-like behavior is yet not fully known. In the present study we introduce a novel GalR2 selective agonist and demonstrate its ability to produce actions consistent with theorized GalR2 functions and analogous to that of the anti-depressant, imipramine.

Place, publisher, year, edition, pages
2013. Vol. 38, no 2, 398-404 p.
Keyword [en]
Galanin, Galaninreceptor type 2, Depression, Agonist, GPCR, Neuropeptide
National Category
Biochemistry and Molecular Biology Neurosciences
Research subject
Neurochemistry with Molecular Neurobiology
URN: urn:nbn:se:su:diva-84943DOI: 10.1007/s11064-012-0933-8ISI: 000313520400018PubMedID: 23192661OAI: diva2:582060
Swedish Research CouncilKnut and Alice Wallenberg Foundation
Available from: 2013-01-03 Created: 2013-01-03 Last updated: 2015-04-21Bibliographically approved

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Runesson, JohanLangel, Ülo
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