Novel Galanin Receptor Subtype Specific Ligand in Depression Like Behavior
2013 (English)In: Neurochemical Research, ISSN 0364-3190, E-ISSN 1573-6903, Vol. 38, no 2, 398-404 p.Article in journal (Refereed) Published
Neuropeptide galanin and its three receptors, galanin receptor type 1-galanin receptor type 3, are known to be involved in the regulation of numerous psychological processes, including depression. Studies have suggested that stimulation of galanin receptor type 2 (GalR2) leads to attenuation of the depression-like behavior in animals. However, due to the lack of highly selective galanin subtype specific ligands the involvement of different receptors in depression-like behavior is yet not fully known. In the present study we introduce a novel GalR2 selective agonist and demonstrate its ability to produce actions consistent with theorized GalR2 functions and analogous to that of the anti-depressant, imipramine.
Place, publisher, year, edition, pages
2013. Vol. 38, no 2, 398-404 p.
Galanin, Galaninreceptor type 2, Depression, Agonist, GPCR, Neuropeptide
Biochemistry and Molecular Biology Neurosciences
Research subject Neurochemistry with Molecular Neurobiology
IdentifiersURN: urn:nbn:se:su:diva-84943DOI: 10.1007/s11064-012-0933-8ISI: 000313520400018PubMedID: 23192661OAI: oai:DiVA.org:su-84943DiVA: diva2:582060
FunderSwedish Research CouncilKnut and Alice Wallenberg Foundation