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Genomic occupancy of the transcriptional co-activators p300 and CBP.
Stockholm University, Faculty of Science, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, The Wenner-Gren Institute.
2012 (English)In: Transcription, ISSN 2154-1272, Vol. 4, no 1, 18-23 p.Article in journal (Refereed) Published
Abstract [en]

The p300 and CBP co-activators are histone acetylases and central regulators of transcription in metazoans. The genomic occupancy of p300/CBP detected by ChIP-seq experiments can be used to identify transcriptional enhancers. However, studies in Drosophila embryos suggest that there is a preference for some transcription factors in directing p300/CBP to the genome. Although p300/CBP occupancy in general correlates with gene activation, they can also be found at silent genomic regions, which does not result in histone acetylation. Polycomb-mediated H3K27me3 is associated with repression, but does not preclude p300/CBP binding. An antagonism between H3K27ac and H3K27me3 indicates that p300/CBP may be involved in switching between repressed and active chromatin states.

Place, publisher, year, edition, pages
2012. Vol. 4, no 1, 18-23 p.
National Category
Developmental Biology
URN: urn:nbn:se:su:diva-85850DOI: 10.4161/trns.22601PubMedID: 23131664OAI: diva2:585152
Available from: 2013-01-09 Created: 2013-01-09 Last updated: 2013-02-28Bibliographically approved

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Holmqvist, Per-HenrikMannervik, Mattias
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