Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Genomic occupancy of the transcriptional co-activators p300 and CBP.
Stockholm University, Faculty of Science, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, The Wenner-Gren Institute.
2012 (English)In: Transcription, ISSN 2154-1272, Vol. 4, no 1, 18-23 p.Article in journal (Refereed) Published
Abstract [en]

The p300 and CBP co-activators are histone acetylases and central regulators of transcription in metazoans. The genomic occupancy of p300/CBP detected by ChIP-seq experiments can be used to identify transcriptional enhancers. However, studies in Drosophila embryos suggest that there is a preference for some transcription factors in directing p300/CBP to the genome. Although p300/CBP occupancy in general correlates with gene activation, they can also be found at silent genomic regions, which does not result in histone acetylation. Polycomb-mediated H3K27me3 is associated with repression, but does not preclude p300/CBP binding. An antagonism between H3K27ac and H3K27me3 indicates that p300/CBP may be involved in switching between repressed and active chromatin states.

Place, publisher, year, edition, pages
2012. Vol. 4, no 1, 18-23 p.
National Category
Developmental Biology
Identifiers
URN: urn:nbn:se:su:diva-85850DOI: 10.4161/trns.22601PubMedID: 23131664OAI: oai:DiVA.org:su-85850DiVA: diva2:585152
Available from: 2013-01-09 Created: 2013-01-09 Last updated: 2013-02-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Holmqvist, Per-HenrikMannervik, Mattias
By organisation
The Wenner-Gren Institute
Developmental Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 181 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf