Change search
ReferencesLink to record
Permanent link

Direct link
Lipid-lowering treatment is related to decreased risk of dementia: a population-based study (FINRISK)
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Show others and affiliations
2010 (English)In: Neurodegenerative diseases, ISSN 1660-2862, Vol. 7, no 1-3, 180-182 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Several lines of evidence have linked cholesterol to dementia.

OBJECTIVE: To investigate lipid-lowering drug use and dementia development in a Finnish population.

METHODS: FINRISK is a large population-based survey of cardiovascular risk factors carried out since 1972 every 5 years using independent, random and representative population samples from different parts of Finland. Several cohorts were part of the WHO-MONICA study. Data from cohorts 1972-2002 were linked to the Hospital Discharge Registry and Drug Reimbursement Registry (1995-2007) to ascertain dementia diagnoses and lipid-lowering treatment. Selection criteria for the study were: (1) alive and without dementia in 1995; (2) age > or = 60 years (in 1995 for earlier cohorts and in 1997 or 2002 for later cohorts; (3) treatment prescribed at least 1 year before dementia diagnosis.

RESULTS: 17,597 persons were included in the study. Lipid-lowering treatment was related to decreased dementia risk. In Cox proportional hazards model, hazard ratio (95% CI) was 0.42 (0.37-0.49; controlled for age, sex, education, survey region, survey year, baseline cholesterol, body mass index and systolic blood pressure).

CONCLUSION: Preliminary results from the FINRISK study indicate that lipid-lowering drugs may have a beneficial effect in dementia prevention. Further data linkage is ongoing in order to investigate the roles of different types of lipid-lowering drugs.

Place, publisher, year, edition, pages
2010. Vol. 7, no 1-3, 180-182 p.
National Category
Gerontology, specializing in Medical and Health Sciences
URN: urn:nbn:se:su:diva-85365DOI: 10.1159/000295659PubMedID: 20224281OAI: diva2:585349
Available from: 2013-01-10 Created: 2013-01-08 Last updated: 2015-09-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Aging Research Center (ARC), (together with KI)
Gerontology, specializing in Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 13 hits
ReferencesLink to record
Permanent link

Direct link