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Memory aging and brain maintenance
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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2012 (English)In: Trends in cognitive sciences, ISSN 1364-6613, E-ISSN 1879-307X, Vol. 16, no 5, 292-305 p.Article, review/survey (Refereed) Published
Abstract [en]

Episodic memory and working memory decline with advancing age. Nevertheless, large-scale population-based studies document well-preserved memory functioning in some older individuals. The influential ‘reserve’ notion holds that individual differences in brain characteristics or in the manner people process tasks allow some individuals to cope better than others with brain pathology and hence show preserved memory performance. Here, we discuss a complementary concept, that of brain maintenance (or relative lack of brain pathology), and argue that it constitutes the primary determinant of successful memory aging. We discuss evidence for brain maintenance at different levels: cellular, neurochemical, gray- and white-matter integrity, and systems-level activation patterns. Various genetic and lifestyle factors support brain maintenance in aging and interventions may be designed to promote maintenance of brain structure and function in late life.

Place, publisher, year, edition, pages
2012. Vol. 16, no 5, 292-305 p.
National Category
Gerontology, specializing in Medical and Health Sciences Psychology
Identifiers
URN: urn:nbn:se:su:diva-85322DOI: 10.1016/j.tics.2012.04.005PubMedID: 22542563OAI: oai:DiVA.org:su-85322DiVA: diva2:585381
Available from: 2013-01-10 Created: 2013-01-08 Last updated: 2017-12-06Bibliographically approved

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