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Midlife healthy-diet index and late-life dementia and Alzheimer's disease
Department of Neurology, University of Eastern Finland, Kuopio.
Department of Neurology, University of Eastern Finland, Kuopio; Department of Health Promotion and Chronic Disease Prevention, National Institute for Health and Welfare.
Department of Health Promotion and Chronic Disease Prevention, National Institute for Health and Welfare.
Department of Neurology, University of Eastern Finland, Kuopio.
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2011 (English)In: Dementia and geriatric cognitive disorders extra, ISSN 1664-5464, Vol. 1, no 1, 103-112 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD). METHODS: Of 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0-17) was constructed including both healthy and unhealthy dietary components. RESULTS: Persons with a healthy diet (healthy-diet index >8 points) had a decreased risk of dementia (OR 0.12, 95% CI 0.02-0.85) and AD (OR 0.08, 95% CI 0.01-0.89) compared with persons with an unhealthy diet (0-8 points), adjusting for several possible confounders. CONCLUSIONS: Healthy diet at midlife is associated with a decreased risk of dementia/AD in late life. These findings highlight the importance of dietary patterns and may make more effective measures for dementia/AD prevention or postponement possible.

Place, publisher, year, edition, pages
Basel: S. Karger, 2011. Vol. 1, no 1, 103-112 p.
Keyword [en]
Alzheimer’s disease, cohort studies, dementia, diet, population-based studies, risk factors
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:su:diva-84986DOI: 10.1159/000327518PubMedID: 22163237OAI: oai:DiVA.org:su-84986DiVA: diva2:585498
Available from: 2013-01-10 Created: 2013-01-04 Last updated: 2013-09-17Bibliographically approved

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Aging Research Center (ARC), (together with KI)
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