Midlife healthy-diet index and late-life dementia and Alzheimer's disease
2011 (English)In: Dementia and geriatric cognitive disorders extra, ISSN 1664-5464, Vol. 1, no 1, 103-112 p.Article in journal (Refereed) Published
AIM: To study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD). METHODS: Of 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0-17) was constructed including both healthy and unhealthy dietary components. RESULTS: Persons with a healthy diet (healthy-diet index >8 points) had a decreased risk of dementia (OR 0.12, 95% CI 0.02-0.85) and AD (OR 0.08, 95% CI 0.01-0.89) compared with persons with an unhealthy diet (0-8 points), adjusting for several possible confounders. CONCLUSIONS: Healthy diet at midlife is associated with a decreased risk of dementia/AD in late life. These findings highlight the importance of dietary patterns and may make more effective measures for dementia/AD prevention or postponement possible.
Place, publisher, year, edition, pages
Basel: S. Karger, 2011. Vol. 1, no 1, 103-112 p.
Alzheimer’s disease, cohort studies, dementia, diet, population-based studies, risk factors
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:su:diva-84986DOI: 10.1159/000327518PubMedID: 22163237OAI: oai:DiVA.org:su-84986DiVA: diva2:585498