Effects of working-memory training on striatal dopamine release
2011 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 333, no 6043, 718- p.Article in journal (Refereed) Published
Updating of working memory has been associated with striato-frontal brain regions and phasic dopaminergic neurotransmission. We assessed raclopride binding to striatal dopamine (DA) D2 receptors during a letter-updating task and a control condition before and after 5 weeks of updating training. Results showed that updating affected DA activity before training and that training further increased striatal DA release during updating. These findings highlight the pivotal role of transient neural processes associated with D2 receptor activity in working memory.
Place, publisher, year, edition, pages
2011. Vol. 333, no 6043, 718- p.
IdentifiersURN: urn:nbn:se:su:diva-84274DOI: 10.1126/science.1204978PubMedID: 21817043OAI: oai:DiVA.org:su-84274DiVA: diva2:585513