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Amidst the green Metal-catalyzed amide formation from carboxylic acids
Stockholm University, Faculty of Science, Department of Organic Chemistry.
2012 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis describes novel methods for transition metal-catalyzed transformation of non-activated carboxylic acids to amides. It was found that 2-10 mol% of zirconium(IV) chloride or 10-20 mol% titanium(IV) isopropoxide catalyzed the formation of a range of secondary and tertiary amides in good to excellent yields (61-99%) in THF at 70-100°C, with molecular sieves present as water scavengers. The protocols proved to be suitable for gram scale preparation of amides, where a straight-forward work-up procedure was used for the isolation of the amide products. Furthermore, it was found that ammonium carbamates were suitable equivalents for gaseous ammonia and dimethylamine, in the group (IV) metal-catalyzed amidation of structurally different carboxylic acids, resulting in good to excellent yields (61-99%) of primary and N,N-dimethyl amides.

Place, publisher, year, edition, pages
Stockholms universitets förlag, 2012. , 27 p.
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:su:diva-86796OAI: oai:DiVA.org:su-86796DiVA: diva2:589658
Presentation
2012-10-26, Room A501-507, Svante Arrhenius väg 16 C, 15:45 (English)
Available from: 2013-01-18 Created: 2013-01-18 Last updated: 2013-01-18Bibliographically approved

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