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Guanosine diphosphate exerts a lower effect on superoxide release from mitochondrial matrix in the brains of uncoupling protein-2 knockout mice: New evidence for a putative novel function of uncoupling proteins as superoxide anion transporters
Stockholm University, Faculty of Science, The Wenner-Gren Institute.
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2012 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 428, no 2, 234-238 p.Article in journal (Refereed) Published
Abstract [en]

In this report, we show new experimental evidence that, in mouse brain mitochondria, uncoupling protein-2 (UCP2) can be involved in superoxide (O-2(center dot-)) removal from the mitochondrial matrix. We found that the effect of guanosine 5'-diphosphate (GDP) on the rate of reactive oxygen species (ROS) release from brain mitochondria of UCP2 knockout mice was less Pronounced compared to the wild type animals. This putative novel UCP2 activity, evaluated by the use of UCP2-knockout transgenic animals, along with the known antioxidant defence systems, may provide additional protection from ROS in brain mitochondria.

Place, publisher, year, edition, pages
2012. Vol. 428, no 2, 234-238 p.
Keyword [en]
Brain mitochondria, Uncoupling protein-2, Reactive oxygen species, Superoxide, Antioxidant defence
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:su:diva-87134DOI: 10.1016/j.bbrc.2012.10.025ISI: 000312431900006OAI: diva2:601332


Available from: 2013-01-29 Created: 2013-01-28 Last updated: 2013-01-29Bibliographically approved

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Shabalina, Irina
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