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Cell-penetrating peptides: from cell cultures to in vivo applications
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0002-4604-6413
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-8813-1096
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-6107-0844
2013 (English)In: Frontiers in Bioscience (Elite Edition), ISSN 1945-0494, E-ISSN 1945-0508, Vol. 5, 509-516 p.Article, review/survey (Refereed) Published
Abstract [en]

The field of gene therapy is starting to move towards clinical applications but is currently limited by the lack of efficient delivery systems. Cell-penetrating peptides provide a means of cellular delivery for gene therapy applications as well as delivery of traditional drugs. Using cell-penetrating peptides a range of different cargos have been successfully delivered into a number of cell types, in vitro as well as in vivo. In this review we discuss uptake mechanisms of different cell-penetrating peptides, with or without cargo. The transition from in vitro to in vivoapplications and strategies to increase the bioavailability of cell-penetrating peptides are also discussed.

Place, publisher, year, edition, pages
2013. Vol. 5, 509-516 p.
Keyword [en]
cell-penetrating peptide, cpp, transfection
National Category
Biological Sciences Chemical Sciences
Research subject
Neurochemistry with Molecular Neurobiology
Identifiers
URN: urn:nbn:se:su:diva-87716DOI: 10.2741/E632OAI: oai:DiVA.org:su-87716DiVA: diva2:605844
Available from: 2013-02-15 Created: 2013-02-15 Last updated: 2017-12-06Bibliographically approved

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Regberg, JakobEriksson, N. K. JonasLangel, Ülo
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