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An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations
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2012 (English)In: The Journal of General Physiology, ISSN 0022-1295, E-ISSN 1540-7748, Vol. 140, no 6, 587-594 p.Article in journal (Refereed) Published
Abstract [en]

Developing an understanding of the mechanism of voltage-gated ion channels in molecular terms requires knowledge of the structure of the active and resting conformations. Although the active-state conformation is known from x-ray structures, an atomic resolution structure of a voltage-dependent ion channel in the resting state is not currently available. This has motivated various efforts at using computational modeling methods and molecular dynamics (MD) simulations to provide the missing information. A comparison of recent computational results reveals an emerging consensus on voltage-dependent gating from computational modeling and MD simulations. This progress is highlighted in the broad context of preexisting work about voltage-gated channels.

Place, publisher, year, edition, pages
2012. Vol. 140, no 6, 587-594 p.
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Biological Sciences
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URN: urn:nbn:se:su:diva-87675DOI: 10.1085/jgp.201210873ISI: 000312957100004OAI: oai:DiVA.org:su-87675DiVA: diva2:605907
Note

AuthorCount:11;

Available from: 2013-02-15 Created: 2013-02-14 Last updated: 2017-07-24Bibliographically approved

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Lindahl, Erik
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Department of Biochemistry and BiophysicsScience for Life Laboratory (SciLifeLab)
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