Change search
ReferencesLink to record
Permanent link

Direct link
Galanin, through GalR1 but not GalR2 receptors, decreases motivation at times of high appetitive behavior
Stockholm University, Faculty of Science, Department of Neurochemistry.
Stockholm University, Faculty of Science, Department of Neurochemistry. University of Tartu, Estonia.ORCID iD: 0000-0001-6107-0844
Show others and affiliations
2013 (English)In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 239, 90-93 p.Article in journal (Refereed) Published
Abstract [en]

Galanin is a 29/30-amino acid long neuropeptide that has been implicated in many physiological and behavioral functions. Previous research has shown that i.c.v. administration of galanin strongly stimulates food intake in sated rats when food is freely available, but fails to stimulate this consumption when an operant response requirement is present. Using fixed ratio (FR) schedules, we sought to further clarify galanin's role in motivated behavior by administering galanin i.c.v. to rats working on fixed ratio schedules requiring either a low work condition (FR1) or higher work conditions (FR > 1) to obtain a 0.2% saccharin reward. Rats in the FR > 1 group were assigned to either an FR3, FR5 or FR7 schedule of reinforcement. The rate of reinforcement decreased for only the FR > 1 group as compared to saline controls. Furthermore, injections of GalR1 receptor agonist M617 led to a similar, marginally significant decrease in the number of reinforcers received in the FR > 1 condition, but a decrease was not seen after injections of GalR2 receptor agonist M1153. Taken together, these results show that galanin may be playing a role in decreasing motivation at times of high appetitive behavior, and that this effect is likely mediated by the GalR1 receptor.

Place, publisher, year, edition, pages
2013. Vol. 239, 90-93 p.
Keyword [en]
Motivation, Reward, Neuropeptide, Fixed-ratio
National Category
URN: urn:nbn:se:su:diva-88280DOI: 10.1016/j.bbr.2012.10.045ISI: 000314146600012OAI: diva2:610722


Available from: 2013-03-12 Created: 2013-03-12 Last updated: 2015-04-21Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Runesson, JohanLangel, Ülo
By organisation
Department of Neurochemistry
In the same journal
Behavioural Brain Research

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 67 hits
ReferencesLink to record
Permanent link

Direct link