Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Protein expansion is primarily due to indels in intrinsically disordered regions
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.ORCID iD: 0000-0002-7115-9751
(English)Manuscript (preprint) (Other academic)
Abstract [en]

Proteins evolve not only through point mutations but also by insertion and deletion events, which affect the length of the protein. It is well known that such indel events most frequently occur in surface exposed loops. However, detailed analysis of indel events in distantly related proteins is hampered by the difficulty involved in correctly aligning such sequences. Here, we circumvent this problem by analyzing homologous proteins based on length variation rather than pairwise alignments. We find a surprisingly strong relationship between difference in length and difference in the number of intrinsically disordered residues, where more than half of the length variation can be explained by changes in the number of intrinsically disordered residues. A more detailed analysis reveals that indel events do not induce disorder but rather that already disordered regions accrue indels, suggesting that there is a significantly lowered selective pressure for indels to occur within intrinsically disordered regions.

National Category
Bioinformatics and Systems Biology
Research subject
Biochemistry
Identifiers
URN: urn:nbn:se:su:diva-88551OAI: oai:DiVA.org:su-88551DiVA: diva2:612037
Projects
GeneFun project, contract No: LSHG-CT-2004-503567EDICT project, contract No: FP7-HEALTH-F4-2007-201924
Funder
Swedish Research Council, VRNT 2009-5072Swedish Research Council, VR-M 2010-3555Swedish Research Council, VR-NT 2012-5046EU, FP7, Seventh Framework Programme, 201924
Available from: 2013-03-19 Created: 2013-03-19 Last updated: 2014-11-10Bibliographically approved

Open Access in DiVA

No full text

Search in DiVA

By author/editor
Sagit, RauanLight, SaraElofsson, Arne
By organisation
Department of Biochemistry and Biophysics
Bioinformatics and Systems Biology

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 85 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf