Norepinephrine, through the second messenger cAMP, stimulates cell prolif- eration in a variety of cell types including brown preadipocytes. However, the cell signalling pathway mediating the cAMP mitogenic effect is poorly established, especially in physiologically relevant systems. A change in tran- scriptional profile due to the activation of specific transcription factors is an important part of intracellular signalling activated by various extracellular stimulants. In the present study, we have used brown preadipocytes as a model system to investigate novel genes that are involved in cAMP-induced cell growth. Based on data from a genome-wide microarray study, 18 genes upregulated by NE in brown preadipocyte were selected for further study. These genes were later confirmed with RT-qPCR to be upregulated by both norepinephrine and forskolin, indicating that they are truly under the positive regulation of cAMP. We therefore suggest that these genes, namely: Ado- ra2b, Arhgap8, Fgf18, Gpr133, Prr5, Tmem37, Twist2 and Ube2s, may be candidates involved in cAMP-stimulated cell proliferation.