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Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia and Italy - relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project)
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
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2013 (English)In: Biomarkers, ISSN 1354-750X, E-ISSN 1366-5804, Vol. 18, no 2, 165-173 p.Article in journal (Refereed) Published
Abstract [en]

Exposure of the general population to polycyclic aromatic hydrocarbons (PAH) is ubiquitous. The aim of this study was to analyze biomarkers associated with the uptake of PAH in 428 non-smoking women from Lodz (Poland), Viterbo (Italy), Belgrade (Serbia) and from the Pancevo area, where the petrochemical complex was destroyed by the air raids in 1999. Urinary excretion of PAH metabolites was lowest in Italian women, intermediary for Serbian and highest in Polish women, who predominantly excreted hydroxy phenanthrenes as metabolites of phenanthrene. Bulky DNA adduct levels were highest in Italian and Polish women. Genotype or PAH ambient air levels could not explain the dissimilarities between the study groups with respect to biomarker patterns, which probably reflected differences in life style-associated factors.

Place, publisher, year, edition, pages
2013. Vol. 18, no 2, 165-173 p.
Keyword [en]
Biomarkers, diet, DNA adducts, genotyping, metabolism, polycyclic aromatic hydrocarbons, polymorphism
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:su:diva-88703DOI: 10.3109/1354750X.2012.762807ISI: 000314976000010OAI: oai:DiVA.org:su-88703DiVA: diva2:612871
Note

AuthorCount:15;

Available from: 2013-03-25 Created: 2013-03-25 Last updated: 2017-12-06Bibliographically approved

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