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N-Acyl taurines trigger insulin secretion by increasing calcium flux in pancreatic beta-cells
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
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2013 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 430, no 1, 54-59 p.Article in journal (Refereed) Published
Abstract [en]

Pancreatic beta-cells secrete insulin in response to various stimuli to control blood glucose levels. This insulin release is the result of a complex interplay between signaling, membrane potential and intracellular calcium levels. Various nutritional and hormonal factors are involved in regulating this process. N-Acyl taurines are a group of fatty acids which are amidated (or conjugated) to taurine and little is known about their physiological functions. In this study, treatment of pancreatic beta-cell lines (HIT-T15) and rat islet cell lines (INS-1) with N-acyl taurines (N-arachidonoyl taurine and N-oleoyl taurine), induced a high frequency of calcium oscillations in these cells. Treatment with N-arachidonoyl taurine and N-oleoyl taurine also resulted in a significant increase in insulin secretion from pancreatic beta-cell lines as determined by insulin release assay and immunofluorescence (p < 0.05). Our data also show that the transient receptor potential vanilloid 1 (TRPV1) channel is involved in insulin secretion in response to N-arachidonoyl taurine and N-oleoyl taurine treatment. However our data also suggest that receptors other than TRPV1 are involved in the insulin secretion response to treatment with N-oleoyl taurine.

Place, publisher, year, edition, pages
2013. Vol. 430, no 1, 54-59 p.
Keyword [en]
N-Arachidonoyl taurine, N-Oleoyl taurine, Insulin secretion, Transient receptor potential vanilloid, receptor 1 (TRPV1), Pancreatic beta-cells
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-88357DOI: 10.1016/j.bbrc.2012.11.026ISI: 000314320700010OAI: oai:DiVA.org:su-88357DiVA: diva2:613018
Note

AuthorCount:5;

Available from: 2013-03-26 Created: 2013-03-13 Last updated: 2017-12-06Bibliographically approved

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Waluk, Dominik P.Aro, Helena
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