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Extracting intracellular diffusive states and transition rates from single-molecule tracking data
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2013 (English)In: Nature Methods, ISSN 1548-7091, E-ISSN 1548-7105, Vol. 10, no 3, 265-269 p.Article in journal (Refereed) Published
Abstract [en]

We provide an analytical tool based on a variational Bayesian treatment of hidden Markov models to combine the information from thousands of short single-molecule trajectories of intracellularly diffusing proteins. The method identifies the number of diffusive states and the state transition rates. Using this method we have created an objective interaction map for Hfq, a protein that mediates interactions between small regulatory RNAs and their mRNA targets.

Place, publisher, year, edition, pages
2013. Vol. 10, no 3, 265-269 p.
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Biochemistry and Molecular Biology
URN: urn:nbn:se:su:diva-89876DOI: 10.1038/NMETH.2367ISI: 000316650800026OAI: diva2:621247


Available from: 2013-05-14 Created: 2013-05-14 Last updated: 2013-05-14Bibliographically approved

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Lindén, Martin
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