Cytokine dysregulation associated with malarial anemia in Plasmodium yoelii infected mice
2013 (English)In: American Journal of Translational Research, ISSN 1943-8141, Vol. 5, no 2, 235-245 p.Article in journal (Refereed) Published
The mechanisms of malaria anemia remain incompletely understood although much effort has been put on studies in both human and murine systems. Hematopoiesis is regulated by the proliferation, differentiation and maturation of erythropoietic progenitor cells into erythrocytes and is tightly controlled by a complex communication network of cytokines as signal mediators. The present study used the murine P. yoelii 17XNL malaria model to investigate the profile of cytokines and leukocytes throughout the entire infection. Moreover, malaria induced anemia was studied in comparison with anemia induced by hemorrhage and hemolysis. During the P. yoelii infection, the levels of erythropoietic-related cytokines, such as G-CSF, GMCSF, IL-7, and IL-17, were pronouncedly reduced, while those of regulatory cytokines, such as IL-10 and TNF-alpha, were constantly increased. This cytokine profile corresponded well with the cellular composition during the infection, such as drastically decreased levels of CD4(+) and CD8(+) T cells. The profiles of erythropoiesis or hematopoiesis related cytokines during malarial anemia showed striking differences from those during anemia induced by hemorrhage or hemolysis. This study demonstrates that a markedly dysregulated cytokine network occurred in this murine malaria model, which may open a new window of insight into the mechanisms of malaria related anemia.
Place, publisher, year, edition, pages
2013. Vol. 5, no 2, 235-245 p.
Malaria, Plasmodium yoelii, anemia, hematopoiesis, IL-7, IL-17, Epo, cytokine
Cancer and Oncology Medical Biotechnology
IdentifiersURN: urn:nbn:se:su:diva-90808ISI: 000318281300011OAI: oai:DiVA.org:su-90808DiVA: diva2:627603
FunderNIH (National Institute of Health), 5 P50 HL 54459-09Swedish Research Council