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Dopamine restores reward prediction errors in old age
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). University College London.
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2013 (English)In: Nature Neuroscience, ISSN 1097-6256, Vol. 16, no 5, 648-+ p.Article in journal (Refereed) Published
Abstract [en]

Senescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value, resulting in an incomplete reward prediction error (RPE) signal in the nucleus accumbens, a brain region that receives rich input projections from substantia nigra/ventral tegmental area (SN/VTA) dopaminergic neurons. Structural connectivity between SN/VTA and striatum, measured by diffusion tensor imaging, was tightly coupled to inter-individual differences in the expression of this expected reward value signal. The dopamine precursor levodopa (L-DOPA) increased the task-based learning rate and task performance in some older adults to the level of young adults. This drug effect was linked to restoration of a canonical neural RPE. Our results identify a neurochemical signature underlying abnormal reward processing in older adults and indicate that this can be modulated by L-DOPA.

Place, publisher, year, edition, pages
2013. Vol. 16, no 5, 648-+ p.
National Category
Neurosciences Neurology
URN: urn:nbn:se:su:diva-90356DOI: 10.1038/nn.3364ISI: 000318029300022OAI: diva2:631368
Wellcome trust, 078865/Z/05/ZWellcome trust, 091593/Z/10/ZWellcome trust, WT088286MA


Available from: 2013-06-20 Created: 2013-06-03 Last updated: 2013-06-24Bibliographically approved

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