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Vectorization of splice-correcting oligonucleotides with cell-penetrating peptides
Stockholm University, Faculty of Science, Department of Neurochemistry. University of Tartu, Estonia.ORCID iD: 0000-0001-6107-0844
2013 (English)In: Chimica oggi, ISSN 0392-839X, E-ISSN 1973-8250, Vol. 31, no 2, 12-15 p.Article in journal (Refereed) Published
Abstract [en]

Personalized medicine approaches based on different gene therapy settings have gained much attention lately. In order to enforce successful gene therapy, genetic material needs to be delivered into cells. Nucleic acids and their analogues are unable to do so and thus require assistance to reach their site of action residing in the cytoplasm or nucleus. Here we give a short review on recent advancements in cell-penetrating peptide mediated delivery of splice-correcting oligonucleotides. We report on different cell-penetrating peptides applied for vectorization of splice-correcting oligonucleotides using both covalent conjugation and non-covalent nanoparticle formation approach. While covalent conjugation has gained extensive interest, there have also been great advances in non-covalent complex formation.

Place, publisher, year, edition, pages
2013. Vol. 31, no 2, 12-15 p.
Keyword [en]
cell-penetrating peptide, splice-correcting oligonucleotide, oligonucleotide delivery, nanoparticle
National Category
Medical Biotechnology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:su:diva-91540ISI: 000319215400003OAI: oai:DiVA.org:su-91540DiVA: diva2:634484
Note

AuthorCount:2;

Available from: 2013-07-01 Created: 2013-06-28 Last updated: 2017-12-06Bibliographically approved

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