Vectorization of splice-correcting oligonucleotides with cell-penetrating peptides
2013 (English)In: Chimica oggi, ISSN 0392-839X, Vol. 31, no 2, 12-15 p.Article in journal (Refereed) Published
Personalized medicine approaches based on different gene therapy settings have gained much attention lately. In order to enforce successful gene therapy, genetic material needs to be delivered into cells. Nucleic acids and their analogues are unable to do so and thus require assistance to reach their site of action residing in the cytoplasm or nucleus. Here we give a short review on recent advancements in cell-penetrating peptide mediated delivery of splice-correcting oligonucleotides. We report on different cell-penetrating peptides applied for vectorization of splice-correcting oligonucleotides using both covalent conjugation and non-covalent nanoparticle formation approach. While covalent conjugation has gained extensive interest, there have also been great advances in non-covalent complex formation.
Place, publisher, year, edition, pages
2013. Vol. 31, no 2, 12-15 p.
cell-penetrating peptide, splice-correcting oligonucleotide, oligonucleotide delivery, nanoparticle
Medical Biotechnology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
IdentifiersURN: urn:nbn:se:su:diva-91540ISI: 000319215400003OAI: oai:DiVA.org:su-91540DiVA: diva2:634484