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A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry
Stockholm University, Faculty of Science, Department of Analytical Chemistry.
2013 (English)In: Journal of Separation Science, ISSN 1615-9306, E-ISSN 1615-9314, Vol. 36, no 8, 1370-1378 p.Article in journal (Refereed) Published
Abstract [en]

Different compositions of monoterpenes are utilized for their pleasant scent in cosmetics and perfumes. However, the most commonly used fragrance terpenes easily oxidize upon contact with air, forming strongly skin-sensitizing hydroperoxides. Due to their thermolability and low UV absorbance, detection methods for hydroperoxides are scarce. For the first time, a simple and sensitive method using LC/ESI-MS/MS was developed to quantitatively determine hydroperoxides from the common fragrance compounds linalool, linalyl acetate, and limonene. The method was applied to autoxidized petitgrain oil and sweet orange oil. A separation was accomplished using a C3 column. The method LOD for the investigated hydroperoxides in the essential oils was below 0.3 g/mL, corresponding to 0.3 ppm. For prevention purposes and according to EU regulations, concentrations in cosmetics exceeding 100 ppm in rinse-off and 10 ppm in stay-on products of linalool and limonene must be labeled. However, the products may still contain allergens, such as hydroperoxides, formed by oxidative degradation of their parent terpenes. The sensitivity and selectivity of the presented LC/MS/MS method enables detection of hydroperoxides from the fragrance terpenes linalool, linalyl acetate, and limonene. However, for routine measurements, the method requires further validation.

Place, publisher, year, edition, pages
2013. Vol. 36, no 8, 1370-1378 p.
Keyword [en]
Autoxidation, Contact allergy, Fragrance terpenes, Hydroperoxides, Liquid chromatography-tandem mass spectrometry
National Category
Analytical Chemistry
URN: urn:nbn:se:su:diva-91537DOI: 10.1002/jssc.201200855ISI: 000319866000007OAI: diva2:634502


Available from: 2013-07-01 Created: 2013-06-28 Last updated: 2013-07-01Bibliographically approved

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Nilsson, Ulrika
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