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Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women
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2013 (English)In: Journal of Reproductive Immunology, ISSN 0165-0378, E-ISSN 1872-7603, Vol. 98, no 1-2, 21-28 p.Article in journal (Refereed) Published
Abstract [en]

Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4(+) T cells declined significantly, contrasting with a non-significant increase in CD8(+) T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.

Place, publisher, year, edition, pages
2013. Vol. 98, no 1-2, 21-28 p.
Keyword [en]
Pregnancy, Peripheral blood mononuclear cells, African women, Longitudinal cohort study, Lymphocytes, Antigen-presenting cells
National Category
Immunology
Identifiers
URN: urn:nbn:se:su:diva-92134DOI: 10.1016/j.jri.2013.03.002ISI: 000320220500003OAI: oai:DiVA.org:su-92134DiVA: diva2:637779
Funder
EU, FP7, Seventh Framework Programme, 200889
Note

AuthorCount:9;

Available from: 2013-07-22 Created: 2013-07-19 Last updated: 2017-12-06Bibliographically approved

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Troye-Blomberg, Marita
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Department of Molecular Biosciences, The Wenner-Gren Institute
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