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Alkaloids from Galipea longiflora Krause modify the maturation of human dendritic cells and their ability to stimulate allogeneic CD4(+) T cells
Stockholm University, Faculty of Science, The Wenner-Gren Institute, Immunology. National University Hospital of Iceland.
Stockholm University, Faculty of Science, The Wenner-Gren Institute, Immunology.
Stockholm University, Faculty of Science, The Wenner-Gren Institute, Immunology.
2013 (English)In: International Immunopharmacology, ISSN 1567-5769, E-ISSN 1878-1705, Vol. 16, no 1, 79-84 p.Article in journal (Refereed) Published
Abstract [en]

Alkaloids obtained from the plant Evanta have been shown to have dual effects in Leishmania infection; a direct leishmanicidal effect on the parasite and more importantly, the alkaloids affect both polyclonal and Leishmania-specific stimulation of T-cells. Dendritic cells (DCs) play a pivotal role in stimulation and polarization of naive T cells towards a Th1, Th2, Th17 or regulatory phenotype. In leishmaniasis, the interactions between the parasites and DCs are complex and involve contradictory functions that can stimulate or suppress T cell responses, leading to the control of infection or progression of disease. In this study the effect of an alkaloid extract of Evanta (AEE) or the purified alkaloid 2-phenilquinoline (2Ph) on the activation of human DCs and their ability to stimulate allogeneic CD4(+) T cells was analyzed. The expression of surface activation molecules was not affected on DCs stimulated in the presence of AEE or 2Ph nor did AEE-DCs or 2Ph-CDs affect the expression of activation surface molecules on allogeneic CD4(+) T cells. In contrast, as compared with control, the secretion of IL-12p40, IL-23 and IL-6 was lower from AEE-DCs and 2Ph-CDs and allogeneic CD4(+) T cells co-cultured with these DCs secreted lower levels of IFN-gamma and IL-10 but the same levels of IL-17. These results demonstrate that AEE and 2Ph affect the stimulation of DCs and their ability to stimulate allogeneic CD4(+) T cells by reducing the production of IFN-gamma, IL-12 p40, IL-6 and IL-23. This suggests that AEE and 2Ph may take part in regulation of inflammation.

Place, publisher, year, edition, pages
2013. Vol. 16, no 1, 79-84 p.
Keyword [en]
Leishmaniasis, Galipea longiflora Krause, Natural products, Dendritic cells, Cytokines
National Category
Immunology
Identifiers
URN: urn:nbn:se:su:diva-92517DOI: 10.1016/j.intimp.2013.03.022ISI: 000320496300011OAI: oai:DiVA.org:su-92517DiVA: diva2:639739
Note

AuthorCount:4;

Available from: 2013-08-09 Created: 2013-08-07 Last updated: 2017-12-06Bibliographically approved

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