Risk factors for incident dementia in the very old
2013 (English)In: International psychogeriatrics, ISSN 1041-6102, E-ISSN 1741-203X, Vol. 25, no 7, 1135-1143 p.Article in journal (Refereed) Published
Background: Several risk factors for dementia, Alzheimer's disease, and cognitive impairment have been established; however, knowledge about risk factors in the very old population (>= 85 years) is limited. This study describes the association of several baseline factors with dementia in participants aged >= 85 years, and investigates factors associated with a higher risk of incident dementia over five years. Methods: The participants in this population-based cohort study were aged 85, 90, and >= 95 years at baseline (2000-2002). Data were collected during home visits for interviews and testing, from a review of medical records, and/or interviewing the caregiver or next of kin. After five years 212 participants could be followed up concerning incident dementia. Multivariate logistic regression was used. Results: At baseline, 100/353 (28%) of participants had a dementia diagnosis. Over five years, 71/212 (33.5%) participants developed dementia. Few participants with dementia at baseline remained alive after five years (12%). Depression at the baseline and follow-up time were associated with a higher risk of dementia, odds ratio (OR) (95% CI, p-value) 2.91 (1.37-6.16, 0.005) and 1.61 (1.26-2.05, <0.001) respectively. More social contact and a higher Mini-Mental State Examination score at baseline were associated with lower risk of incident dementia, OR (95% CI, p-value) 0.87 (0.78-0.97, 0.009) and 0.83 (0.74-0.93, 0.001) respectively. Conclusions: Prevalence and incidence of dementia are high in very old people and dementia appears to be a fatal disorder. Depression is associated with higher risk of incident dementia over five years whereas more frequent social contacts and a higher MMSE score are associated with lower risk.
Place, publisher, year, edition, pages
2013. Vol. 25, no 7, 1135-1143 p.
aged, 80 and over, longitudinal, population-based, depression, social isolation, prevalence, incidence
IdentifiersURN: urn:nbn:se:su:diva-92635DOI: 10.1017/S1041610213000409ISI: 000321262200011OAI: oai:DiVA.org:su-92635DiVA: diva2:641725