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The impact of splicing on protein domain architecture
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).ORCID iD: 0000-0002-7115-9751
2013 (English)In: Current opinion in structural biology, ISSN 0959-440X, E-ISSN 1879-033X, Vol. 23, no 3, 451-458 p.Article in journal (Refereed) Published
Abstract [en]

Many proteins are composed of protein domains, functional units of common descent. Multidomain forms are common in all eukaryotes making up more than half of the proteome and the evolution of novel domain architecture has been accelerated in metazoans. It is also becoming increasingly clear that alternative splicing is prevalent among vertebrates. Given that protein domains are defined as structurally, functionally and evolutionarily distinct units, one may speculate that some alternative splicing events may lead to clean excisions of protein domains, thus generating a number of different domain architectures from one gene template. However, recent findings indicate that smaller alternative splicing events, in particular in disordered regions, might be more prominent than domain architectural changes.The problem of identifying protein isoforms is, however, still not resolved. Clearly, many splice forms identified through detection of mRNA sequences appear to produce 'nonfunctional' proteins, such as proteins with missing internal secondary structure elements. Here, we review the state of the art methods for identification of functional isoforms and present a summary of what is known, thus far, about alternative splicing with regard to protein domain architectures.

Place, publisher, year, edition, pages
2013. Vol. 23, no 3, 451-458 p.
National Category
Biochemistry and Molecular Biology Cell Biology
Identifiers
URN: urn:nbn:se:su:diva-92814DOI: 10.1016/j.sbi.2013.02.013ISI: 000321408300018OAI: oai:DiVA.org:su-92814DiVA: diva2:642531
Funder
Swedish Research Council, VR-NT 2009-5072 VR-M 2010-3555Swedish Foundation for Strategic Research EU, FP7, Seventh Framework Programme, FP7-HEALTH-F4-2007-201924
Note

AuthorCount:2;

Available from: 2013-08-22 Created: 2013-08-20 Last updated: 2017-12-06Bibliographically approved

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