Solid-State NMR Characterization of the Molecular Conformation in Disordered Methyl alpha-L-Rhamnofuranoside
2013 (English)In: Journal of Physical Chemistry A, ISSN 1089-5639, E-ISSN 1520-5215, Vol. 117, no 26, 5534-5541 p.Article in journal (Refereed) Published
A combination of solid-state C-13 NMR tensor data and DFT computational methods is utilized to predict the conformation in disordered methyl alpha-L-rhamnofuranoside. This previously uncharacterized solid is found to be crystalline and consists of at least six distinct conformations that exchange on the kHz time scale. A total of 66 model structures were evaluated, and six were identified as being consistent with experimental C-13 NMR data. All feasible structures have very similar carbon and oxygen positions and differ most significantly in OH hydrogen orientations. A concerted rearrangement of OH hydrogens is proposed to account for the observed dynamic disorder. This rearrangement is accompanied by smaller changes in ring conformation and is slow enough to be observed on the NMR time scale due to severe steric crowding among ring substituents. The relatively minor differences in non-hydrogen atom positions in the final structures suggest that characterization of a complete crystal structure by X-ray powder diffraction may be feasible.
Place, publisher, year, edition, pages
American Chemical Society (ACS), 2013. Vol. 117, no 26, 5534-5541 p.
Physical Chemistry Atom and Molecular Physics and Optics Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-92801DOI: 10.1021/jp4036666ISI: 000321542500016OAI: oai:DiVA.org:su-92801DiVA: diva2:642748
University of Central Florida Stokes Advanced Research Computing Center2013-08-232013-08-202016-10-03Bibliographically approved